Overview

Pharmaceutical companies face significant challenges in developing a pipeline of safe and effective new drugs. HCS assays are critical for drug discovery and can be used in target identification and validation, lead-compound discovery, selection, and optimization. Insights from these information-rich assays can help researchers discover the most effective drugs more efficiently, while getting flawed compounds to "fail fast," saving considerable time and expense. To best utilize the huge amounts of image data generated by HCS assays, it is essential to have a solution that offers effective data management, image storage, retrieval, mining and analysis capabilities.

CellMine™

CellMineT is developed specifically for HCS applications. CellMineT is a web based instrument independent HCS informatics solution. It seamlessly integrates screening data with images and facilitates linkage to complementary discovery data and compound information. It unlocks the value of cell-based assays by facilitating improved lead selection and optimization. CellMineT is built on BioImagene's 3i specially designed for image management solutions for the life science industry.  

CellMineT automates data transfer from HCS machines directly to SIMST. it also enables integration of HCS data with other experimental data and image to provide a complete picture of a compound under study. 

 

Advantages | Features| View PDF

 

 

 

 

 

 

 

 

 

 

 

Advantages:

Effective workflow automation

• Aggregates data across multiple instruments, screening campaigns and assays.
• Accommodates changes in instrument, plate dimensions, assays, analysis methods and research focus, without loss of system.
• Meaningful extraction of HCS data.
• Integrate with complementary compound biochemical, genomic and toxicology data.
• Powerful data mining across multiple plates and experiments.
• Quick comparison of primary and secondary analysis data.
• Maximizes the ability to identify effective lead compounds from a number of hits.

Fast, efficient image transfer, storage and retrieval

• Quickly searches analysis data and associated images.
• Eliminates repetition by saving proven search strategies that can be rerun.
• Batch loading capability reduces image and data loading time.

Flexible and integrated solution

• Scalable solution that integrates with 3rd party analysis application and visualization tools.
• Single interface to disparate sets of information to make better informed decisions.
• Turnkey solution for acquisition, reporting and web based collaboration of HCS data.

Overview | Features

CellMineT Features:

• Hardware independent. Configurable connectors to multiple HCS instruments.
• Supports over 100 image file formats.

Hierarchical search and data mining

• Hierarchical representation of HCS data defined from screen through field.
• View associated images from plate to well data.
• Perform multi parametric advanced searches.
• Easy analysis reduces time to gain insights.

Plate Viewer

• Data represented as 96 and 384 well plates.
• Cross project, cross plate and cross run comparison capability.
• Heat maps and threshold to demonstrate dose response for given assays.
• Ability to view plate statistics.
• Ability to export images for re-analysis.

Web based collaboration Allows collaboration and sharing of image data between multiple users and locations. Optimally supports workflows by delivering HCS data to preferred applications and researchers as needed. Regulatory compliance 21 CFR part 11 compliant. Supports audit trails, digital signatures, and archive and retrieve features. Enables companies to comply with FDA's preference for fully electronic submissions. Image Management Creates users, assigns roles and access privileges. Annotates images using user-defined fields. Retain image in original format. Image archival, report generation, image navigation and advanced search capabilities. Export images as different file formats. Integration with analysis tools Integrates with image analysis applications such as RavenT, GE InvestigatorT, GE- Develop toolboxT, MetamorphT, ImageJT. Easy import and association of secondary analysis data with primary HCS analysis data. Integration with Spotfire HCS data and images can be visualized in SpotfireT to enable scientists to see trends, patterns and unanticipated relationships in data. Custom Solutions Instrument and application connectors can be customized as per user and workflow requirements. Full implementation cycle including training, development and support.

Overview | Advantages