Companion Algorithms™
Brain Cancer
Common adult tumors of the brain include meningioma, astrocytomas and oligodendroglioma. Astrocytic tumors include pilocytic astrocytoma (grade I), diffuse astrocytoma (WHO grade 2), anaplastic astrocytoma (WHO grade 3) and glioblastoma (WHO grade 4). Accurate differentiation is important as grade is a predictor of survival. Methods currently used for grade assignment include mitotic counts, evidence of necrosis, and microvascular proliferation¹. Recent studies have suggested that immunohistochemistry with the cellular proliferation marker, Ki-67 is useful in the determination between grades 2, 3, and 4². BioImagene's Ki-67 brain algorithm* is an aid to researchers in the detection and quantitation of Ki-67 labeled glial tumor cells in brain cancer samples.
1. Miller CR, et al. Arch Pathol Lab Med 2007 131(3):397-406
2. Torp SH Clin Neuropathol 2002 21(6):252-257
*Ventana test systems are for in vitro diagnostic use for specific clinical applications, and are intended for research use only for other applications
